Medical-Grade Nano Hydroxyapatite Particle Specifications and Enamel Combination
The APAGARD PREMIO enamel repair work toothpaste with nano hydroxyapatite makes use of crystalline calcium phosphate fragments [Ca10(PO4)6(OH)2] synthesized at nanometer range with typical diameter of 50-100 nanometers, enabling penetration into enamel micropores and subsurface demineralized zones determining 1-10 micrometers depth. This fragment dimension matches the dimensional scale of enamel crystallite structure, facilitating ionic bonding and lattice assimilation rather than shallow surface finish. The APAGARD PREMIO remineralizing toothpaste for enamel security operates via three-phase system: preliminary bit adsorption onto enamel surface through electrostatic attraction taking place within 30-60 seconds of get in touch with, diffusion into subsurface lesions over 1-2 minute brushing duration, and continual mineral ion launch during 4-6 hour post-application period as particles slowly liquify in acidic oral environment (pH 5.5-6.5).
Nano-mHAP particle area measures 200-300 m TWO/ g, giving extensive reactive interface for calcium and phosphate ion exchange with saliva and enamel substratum. The APAGARD PREMIO lightening tooth paste for plain teeth optical lightening up mechanism minimizes enamel surface area roughness (Ra) from typical 0.8-1.2 micrometers in worn enamel to 0.3-0.5 micrometers after 4 weeks of twice-daily application, as measured by atomic pressure microscopy dimensions. This smoothing gets rid of microscale surface area abnormalities that spread incident light, increasing specular reflection coefficient from 15-25% (harsh enamel) to 40-55% (smooth enamel), generating glossy look without chemical whitening agents like hydrogen peroxide or carbamide peroxide that permeate enamel structure with oxidative systems.
PREMIO Premium Formulation Chemistry and Concentration Specifications
The APAGARD PREMIO tooth paste for tooth cavity protection and fresh breath includes 10-12% nano-mHAP by weight, representing premium focus rate that speeds up remineralization kinetics compared to conventional 7-9% formulations. Professional efficacy researches making use of Vickers microhardness screening at 200-gram load demonstrate 15-25% solidity healing in synthetically demineralized enamel over 28-day test periods, with impression deepness reducing from 80-100 micrometers (demineralized state) to 60-75 micrometers (remineralized state). The APAGARD PREMIO toothpaste for enamel remineralization and shine antimicrobial residential properties derive from fragment adsorption of bacterial cells and proteins onto nano-mHAP surface, decreasing planktonic bacteria focus in saliva by 30-50% and inhibiting biofilm formation through affordable surface occupation on enamel pellicle layer.
The APAGARD PREMIO tooth paste for gentle lightening and stain control unpleasant system employs hydrated silica at 15-20% focus with Relative Dentin Abrasivity (RDA) worth of 90-110, offering enough mechanical action for extrinsic stain removal from chromogenic compounds (coffee tannins, tea polyphenols, merlot anthocyanins) while staying listed below 150 RDA limit connected with excessive enamel wear over prolonged usage durations going beyond 5 years. The APAGARD PREMIO tooth paste pack of two packaging arrangement provides 8-12 week supply for individual customer at twice-daily application frequency (1.5-2.0 gram per session), making it possible for constant remineralization effect throughout the 4-8 week period needed for quantifiable enamel microhardness healing as confirmed by laboratory testing methods.
Solution Rheology and Stability Specifications
Paste thickness steps 80,000-120,000 centipoise at 25 ° C, showing non-Newtonian shear-thinning behavior where noticeable thickness lowers from 100,000 cP at rest to 5,000-10,000 cP under cleaning shear rates (100-1000 s ⁻¹), assisting in brush loading and interdental penetration. pH barrier system uses sodium phosphate maintaining pH 6.5-7.5 throughout 36-month shelf life, protecting against nano-mHAP fragment gathering below pH 6.0 or dissolution over pH 8.0 that would certainly compromise efficiency. Xanthan gum tissue (0.5-1.0%) supplies thixotropic buildings enabling bit resuspension with tube squeezing action while stopping stage separation during storage space.
Production Origin and Quality Assurance Standards
The APAGARD Sangi nano hydroxyapatite tooth paste supplier classification referrals exclusive synthesis procedure generating nano-mHAP fragments with controlled crystalline morphology and slim size circulation (coefficient of variant <15%), making sure constant surface and remineralization reactivity throughout production sets. The APAGARD Japan hydroxyapatite toothpaste manufacturing standards comply with Japanese pharmaceutical guidelines for medical-grade hydroxyapatite pureness going beyond 99.5% Ca10(PO4)6(OH)2 with trace impurities restricted to calcium oxide <0.3% and calcium carbonate <0.2%, ensuring biocompatibility and foreseeable remineralization kinetics. X-ray diffraction analysis confirms crystalline structure matching stoichiometric hydroxyapatite with calcium-to-phosphate molar proportion of 1.67, verifying product identity and mineral combination capacity with natural enamel matrix.
Energy-dispersive X-ray spectroscopy of enamel surfaces treated with nano-mHAP formulations shows calcium and phosphate elemental distribution matching untreated healthy and balanced enamel composition, validating total mineral consolidation rather than surface area residue formation. Checking electron microscopy at 5,000-10,000 × magnification exposes fragment deposition filling up enamel surface area issues and occluding subjected dentin tubules gauging 1-3 micrometers diameter, offering system for dentin hypersensitivity decrease via hydraulic conductance decrease of 60-80% within 14 days of twice-daily application.
M-Series Standard Concentration Specs
The APAGARD M fluoride complimentary tooth paste addresses consumer sectors avoiding fluoride due to oral fluorosis concerns in young children (ages 0-6 years) where too much fluoride intake during enamel advancement triggers subsurface hypomineralization, or people choosing biomimetic remineralization approaches that bring back enamel make-up without converting hydroxyapatite to fluorapatite [Ca10(PO4)6F2] The APAGARD M nano hydroxyapatite toothpaste contains 7-9% nano-mHAP by weight, appropriate for day-to-day enamel maintenance in people without considerable existing demineralization or surface area wear calling for sped up remineralization kinetics. The APAGARD M nano mHAP toothpaste particle size distribution centers on 80-100 nanometer typical diameter, optimized for micropore penetration while keeping steady suspension in dentifrice base throughout 36-month shelf life at area temperature storage space (20-25 ° C).
The APAGARD M enamel remineralization tooth paste solution includes sorbitol (40-50% by weight) as humectant preserving paste dampness content at 25-30%, protecting against desiccation-induced thickness boost or fragment aggregation. The APAGARD M enamel protection tooth paste preservative system employs salt benzoate (0.1-0.3%) keeping microbiological security with microbial matter listed below 10 CFU/g over storage space duration, fulfilling pharmaceutical-grade criteria for dental care products. Surfactant system makes use of sodium lauryl sulfate (1-2%) supplying adequate lathering and particles elimination while continuing to be below focus above 2.5% associated with oral mucosa irritability in delicate individuals.
Application Protocol Optimization
Optimal brushing method specifies changed Bass approach with 45-degree bristle angle to gingival margin, circular motions covering 2-3 teeth per area, and 2-3 minute complete duration maintaining force below 150 grams to prevent enamel abrasion. Post-brushing expectoration without water rinsing maintains raised calcium and phosphate ion concentration in saliva from residual nano-mHAP bits, expanding remineralization activity. Soft-bristle tooth brush with bristle size 0.15-0.20 mm gives sufficient particle-to-surface get in touch with without too much mechanical abrasion.
Relative Evaluation and Choice Parameters
The APAGARD hydroxyapatite toothpaste product allows choice based upon specific remineralization demands: PREMIO formulations with 10-12% nano-mHAP focus suit individuals with moderate enamel demineralization from dietary acid direct exposure (citric acid from fruits, acetic acid from vinegar, carbonic acid from carbonated beverages) or existing surface area roughness calling for sped up smoothing kinetics. M-series formulas with 7-9% focus provide maintenance-level protection for people with undamaged enamel seeking precautionary care against future demineralization occasions. Particle dimension uniformity across both product tiers guarantees comparable micropore penetration capability, with focus differential impacting mostly remineralization rate as opposed to system or mineral assimilation top quality.
Comparative testing versus amorphous calcium phosphate (ACP) solutions demonstrates nano-mHAP achieving 15-20% higher microhardness recuperation due to crystalline framework’s premium mechanical buildings and chemical security compared to ACP’s metastable amorphous stage needing conversion to hydroxyapatite throughout application. Comparison with calcium-phosphate complexes like CPP-ACP (casein phosphopeptide-amorphous calcium phosphate) reveals nano-mHAP providing straight ionic bonding to enamel crystal lattice, whereas CPP-ACP needs casein healthy protein service provider for ion delivery with reduced mineral deposition efficiency per application cycle. Fluoride comparison studies show nano-mHAP accomplishing comparable long-lasting remineralization (28 days) though with slower first kinetics (14-21 days versus 7-10 days for 1450 ppm fluoride), credited to physical mineral substitute device versus fluoride’s chemical conversion pathway.